2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154283
    2-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)purine
    2-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)purine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    2-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)purine
  • HY-152713
    3’-Azido-3’-deoxy-5-methoxyuridine
    3’-Azido-3’-deoxy-5-methoxyuridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-5-methoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3’-Azido-3’-deoxy-5-methoxyuridine
  • HY-W560807
    5’-O-(4,4’-Dimethoxytrityl)-2’-O-t-butyldimethylsilyl adenosine
    5’-O-(4,4’-Dimethoxytrityl)-2’-O-t-butyldimethylsilyl adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    5’-O-(4,4’-Dimethoxytrityl)-2’-O-t-butyldimethylsilyl adenosine
  • HY-154077
    N4-Benzoyl-5-methyl-2’-O,4’-C-methylenecytidine
    N4-Benzoyl-5-methyl-2’-O,4’-C-methylenecytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    N4-Benzoyl-5-methyl-2’-O,4’-C-methylenecytidine
  • HY-154722
    N6-Dimethylaminomethylidene isoguanosine
    N6-Dimethylaminomethylidene isoguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N6-Dimethylaminomethylidene isoguanosine
  • HY-152482
    3’-O-(2-Methoxyethyl)-2-thiouridine
    3’-O-(2-Methoxyethyl)-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-O-(2-Methoxyethyl)-2-thiouridine
  • HY-154507
    N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine
    N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
    N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine
  • HY-N17703
    Indolylmethyl-desulfoglucosinolate
    Indolylmethyl-desulfoglucosinolate is a glucosinolate metabolism.
    Indolylmethyl-desulfoglucosinolate
  • HY-154403
    2’-Azido-2’-deoxy-5’-O-(4,4’-dimethoxytrityl)-5-methyluridine
    2’-Azido-2’-deoxy-5’-O-(4,4’-dimethoxytrityl)-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Azido-2’-deoxy-5’-O-(4,4’-dimethoxytrityl)-5-methyluridine
  • HY-180710
    N-Phosphotaurocyamine
    N-Phosphotaurocyamine (Taurocyamine phosphate) is a phosphagen in Arenicola, the stores of phosphotaurocyamine are an energy source which can be used for rapid regeneration of ATP.
    N-Phosphotaurocyamine
  • HY-152584
    3’-Deoxy-3’-fluoro-xyloguanosine
    3’-Deoxy-3’-fluoro-xyloguanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-Deoxy-3’-fluoro-xyloguanosine
  • HY-154200
    3’-Deoxy-5-methycytidine
    3’-Deoxy-5-methycytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-Deoxy-5-methycytidine
  • HY-138587
    7-TFA-ap-7-Deaza-ddG
    7-TFA-ap-7-Deaza-ddG (compound 19d, US20060281100A1), a nucleotide derivative, can be used in the synthesis of thiotriphosphate nucleotide dye terminators which can be used in DNA sequencing reactions.
    7-TFA-ap-7-Deaza-ddG
  • HY-131787A
    2-Amino-ATP tetrasodium
    2-Amino-ATP tetrasodium is an ATP substitute produced by inserting an amino acid at the C2 position of ATP.
    2-Amino-ATP tetrasodium
  • HY-152711
    2-Chloro-2’-β-C-methyl-6-N,N-dimethyladenosine
    2-Chloro-2’-β-C-methyl-6-N,N-dimethyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Chloro-2’-β-C-methyl-6-N,N-dimethyladenosine
  • HY-W1143084A
    m7G(5')ppp(5' )(2'OMeG) ammonium
    m7G(5')ppp(5')(2'OMeG) ammonium is a cap analog that can be used for the synthesis of mRNA.
    m7G(5')ppp(5' )(2'OMeG) ammonium
  • HY-152610
    3′-C-Methylguanosine
    3′-C-Methylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
    3′-C-Methylguanosine
  • HY-154454
    3’-Deoxy-2’,5’-di-O-acetyl-8-hydroxyguanosine
    3’-Deoxy-2’,5’-di-O-acetyl-8-hydroxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-Deoxy-2’,5’-di-O-acetyl-8-hydroxyguanosine
  • HY-154528
    2’-O-Phthalimidopropyl cytidine
    2’-O-Phthalimidopropyl cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-O-Phthalimidopropyl cytidine
  • HY-180682
    2-Methoxyestradiol-17beta 3-sulfate
    2-Methoxyestradiol-17beta 3-sulfate is a nucleoside metabolite.
    2-Methoxyestradiol-17beta 3-sulfate